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elegans not subjected to tomatidine, but those who survived this period of elevated Demise experienced a longer maximal lifespan (Figure S1A). This biphasic dose – reaction effect of tomatidine is per a hormesis-based mechanism of action17. We also recognized that fifty μM tomatidine exhibited some toxicity to C. elegans healthspan at the same

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MT dynamics would be the target of a Microtubule-Concentrating on Brokers (MTAs) which Exhibit a dose-dependent anti-proliferative impact. At superior concentrations, MTAs are cytotoxic; they inhibit mobile proliferation by suppressing dynamicity of spindle MTs, which might be important for right chromosome separation in the course of cell division

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